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Whilst exact mechanisms remain unclear, a combination of risk factor reduction in improved HbA1c, weight, metabolic profile, as well as direct effects of GLP-1 agonism on coronary endothelial function and improved microvascular perfusion is likely at play

The effect of GLP-1R agonists on reversing amphetamine-induced locomotion and that liraglutide may act similar to lithium in terms of reversing cognitive deficits and liraglutide decreased lithium-induced weight gain brought the idea that GLP-1 analogs can serve as a potential target for psychostimulant abuse and treatment for bipolar disorder since it can reverse several aspects of mania and drug-induced side effects in bipolar disorder (Chaves Filho et al., Secondly, GLP-1 could have a significant role in psychological stress responses, in addition to mood disorders

Many individuals include glutathione supplements in their wellness routines to help support cellular health, healthy aging, and overall vitality

39 GLP-1RAs and Coronary Artery Disease Epicardial CAD is commonly seen in HFpEF